Compositions and methods for regulated protein expression in...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) C12N 5/071 (2010.01) C07K 14/605 (2006.01) C07K 14/62 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2403205

The invention provides compositions and methods useful for treating disorders treatable by producing a protein in a regulatable manner in a mucosal cell or tissue of an animal. The treatment methods include in vivo and ex vivo methods, including transplanting in vitro transformed cells that secrete the protein into a mammalian subject.

L'invention concerne des compositions et des méthodes destinées à des troubles pouvant être traités par production régulée d'une protéine dans une cellule ou un tissu des muqueuses d'un animal. Ces méthodes de traitement comprennent des méthodes in vivo et ex vivo, et notamment la transplantation de cellules transformées in vitro sécrétant cette protéine chez un sujet mammifère.

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