Compositions and methods for regulating bacterial pathogenesis

Details Compositions and methods for regulating bacterial pathogenesis Compositions and methods for regulating bacterial pathogenesis

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/00 (2006.01) A61K 35/74 (2006.01) A61K 45/00 (2006.01) C12N 1/20 (2006.01) C12N 15/09 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/533 (2006.01) G01N 33/554 (2006.01)

Patent

CA 2351731

This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides a new class of bacterial genes involved in the biosynthesis of the signaling molecule.

Cette invention concerne une molécule de signalisation, purifiée, extracellulaire, d'origine bactérienne, appelée autoinducteur 2 dont la production est régulée par des modifications environnementales accompagnant le passage d'une existence libre à une existence colonisatrice ou pathogène dans un organisme hôte. La molécule de signalisation stimule des gènes de luminescence LuxQ et, apparemment, divers gènes en rapport avec la pathogenèse dans l'espèce bactérienne qui produit ladite molécule. Cette invention concerne également une nouvelle classe de gènes bactériens intervenant dans la biosynthèse de la molécule de signalisation.

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