Compositions and methods for regulating cell osmolarity

Details Compositions and methods for regulating cell osmolarity Compositions and methods for regulating cell osmolarity

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2734922

The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).

La présente invention concerne des compositions et des procédés pour réguler l'osmolarité intracellulaire dans des cellules, par exemple, dans des cellules en culture, comprenant des cellules en culture dans des bioréacteurs. L'invention concerne des acides nucléiques comprenant au moins un élément régulateur transcriptionnel osmo-répondeur (OR-TRE), et des cellules, vecteurs, produits de fabrication, organes artificiels ou implants et similaire, contenant un élément régulateur transcriptionnel osmo-répondeur (OR-TRE).

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