Compositions and methods for regulating cellular signal...

Details Compositions and methods for regulating cellular signal... Compositions and methods for regulating cellular signal...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 9/127 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2132624

2132624 9320439 PCTABS00027 Disclosed is a method of regulating the metabolic pathway of inositol in a cell. This method includes the introduction into said cell of a molecule which is then allowed to couple a membrane-bound receptor, activatable by an external signal, to an intracellular phosphodiesterase of the type responsible for generating second messenger substance, IP3. This molecule is selected from the group consisting of a purified A-protein, and active fragments, active analogs, and active fusion products thereof. Also disclosed are methods of detecting an A-protein and methods of inhibiting the growth and proliferation of cancer cells using anti-A-protein antibodies.

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