A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/57 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2744555
The invention encompasses methods and compositions for increasing or decreasing collagen 1A1 expression and/or .alpha.-smooth muscle actin expression in lung fibroblasts using SERPINE2 and antagonists of SERPINE2. The invention also encompasses methods and compositions for increasing or decreasing the formation of myofibroblasts. The invention further pro-vides methods and compositions for treatment of lung diseases, such as idiopathic pulmonary fibrosis and chronic obstructive pul-monary disease.
La présente invention concerne des procédés et des compositions pour augmenter ou diminuer l'expression de collagène 1A1 et/ou l'expression d'actine de muscle lisse a dans des fibroblastes de poumon en utilisant la SERPINE E2 et des antagonistes de SERPINE E2. L'invention concerne en outre des procédés et des compositions pour augmenter ou diminuer la formation de myofibroblastes. L'invention concerne en outre des procédés et des compositions pour le traitement de maladies pulmonaires, telles que la fibrose pulmonaire idiopathique et la bronchopneumopathie chronique obstructive.
Bhawe Kaumudi
Bosch Elizabeth
Boyle Kathleen
Brace Arthur
Das Anuk
Centocor Research & Development Inc.
Five Prime Therapeutics Inc.
Smart & Biggar
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