C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) C12N 15/62 (2006.01) C12N 15/87 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2390646
The present invention provides compositions and methods for altering mitochondrial ATP production, including binding and functional assays exploiting IF1 interactions with ATP synthase. Also disclosed are methods for screening assays for a compound capable of reducing mitochondrial ATP hydrolysis and/or increasing mitochondrial ATP synthesis, including pharmaceutical compositions identified by such methods. The invention also provides methods for treating diabetes, and in particular, type 2 DM, using an agent identified according to the disclosed methods.
La présente invention concerne des compositions et des méthodes pouvant modifier la production d'ATP mitochondrial, y compris des immunodétections et des dosages fonctionnels exploitant les interactions d'IF1 avec l'ATP-synthase. L'invention concerne aussi des méthodes utilisées dans des dosages de criblage pour un composé pouvant réduire l'hydrolyse de l'ATP mitochondrial et/ou augmenter la synthèse de l'ATP mitochondrial, ainsi que des une compositions pharmaceutiques identifiées par ces méthodes. L'invention concerne en outre des méthodes de traitement du diabète, notamment le diabète non insulino-dépendant, au moyen d'un agent identifié selon les méthodes de l'invention.
Anderson Christen M.
Clevenger William
Gowling Lafleur Henderson Llp
Mitokor
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