Compositions and methods for regulating phagocytosis and...

Details Compositions and methods for regulating phagocytosis and... Compositions and methods for regulating phagocytosis and...

A - Human Necessities

61

K

A61K 38/56 (2006.01) A61K 31/428 (2006.01) A61P 29/00 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2314899

This invention provides compositions of matter for treating and preventing certain mammalian disorders ameliorated by either an increase or decrease in phagocytosis or ICAM-1 expression in appropriate cells. This invention also provides method of altering the phagocytosis or ICAM-1 expression level in a cell. This invention further provides methods of treating and preventing mammalian disorders affected by the alteration of phagocytosis or ICAM-1 expression. The instant methods and composition of matter all relate to the use of agents that specifically increase or decrease phagocytosis or ICAM-1 expression. Finally, this invention provides related articles of manufacture.

L'invention concerne des compositions utiles pour le traitement et la prévention de certains troubles dont sont atteints des mammifères, troubles qui sont atténués par augmentation ou diminution de la phagocytose ou de l'expression de la molécule d'adhésion intercellulaire 1 (ICAM-1) dans des cellules appropriées. L'invention concerne également des procédés d'altération du niveau de phagocytose ou d'expression de l'ICAM-1 dans une cellule, ainsi que des procédés de traitement et de prévention de troubles dont sont atteints des mammifères, et qui sont affectés par l'altération de la phagocytose ou de l'expression de l'ICAM-1. Les procédés et compositions de l'invention ont tous trait à l'utilisation d'agents qui augmentent ou diminuent spécifiquement la phagocytose ou l'expression de l'ICAM-1. Enfin, l'invention concerne des articles manufacturés.

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