Compositions and methods for regulating receptor clustering

Details Compositions and methods for regulating receptor clustering Compositions and methods for regulating receptor clustering

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2433954

The invention relates to isolated complexes comprising one or more galectin associated with a Mgat5 modified glycan or polylactosamine modified glycan, and isolated lectin-Mgt5 modified glycan lattice comprising an array of mulitvalent interactions among lectins, Mgat5 modified glycans, polylactosamine modified glycans, and/or glycoproteins. Methods for evaluating a test compound for its ability to regulate receptor clustering through glycans on cell surfaces; and methods for regulating receptor clustering on cell surfaces comprising altering glycans on the cell surface associated with receptor clustering are also disclosed.

L'invention concerne des complexes isolés comprenant une ou plusieurs galectines associées à un glycane à modification Mgat5 ou un glycane à modification polylactosamine, ainsi qu'un milieu moléculaire de glycanes à modification lectine-Mgt5 comprenant un réseau d'interactions multivalentes entre les lectines, les glycanes à modification Mgat5, les glycanes à modification polylactosamine et/ou les glycoprotéines. L'invention concerne également des méthodes destinées à évaluer la capacité d'un composé d'essai à réguler l'agrégation des récepteurs par l'intermédiaire des glycanes sur les surfaces cellulaires, ainsi que des méthodes destinées à réguler l'agrégation des récepteurs sur les surfaces cellulaires, ces méthodes consistant à modifier les glycanes sur la surface cellulaire associée à l'agrégation des récepteurs.

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