Compositions and methods for repairs of cartilage and bone

Details Compositions and methods for repairs of cartilage and bone Compositions and methods for repairs of cartilage and bone

A - Human Necessities

61

K

167/327

A61K 35/28 (2006.01) A61K 35/34 (2006.01) A61L 27/00 (2006.01)

Patent

CA 1341078

A defect is provided in cartilage or bone, or both, to excise damaged or pathological tissue, and it is filled with an implant having capability for complete regeneration of the skeletal tissue as a chondrogenic or osteogenic phenotype. The implant comprises cells expressing a chondrocyte phenotype (80 x 10 6 cells/ml) embedded in a biocompatible matrix having about 20% serum, which provides a permissive environment for maturation and transformation of the implant to a fully integrated state with the surrounding tissue. A portion of the implant may comprise a bone segment or a bone substitute.

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