Compositions and methods for restoring immune repertoire in...

Details Compositions and methods for restoring immune repertoire in... Compositions and methods for restoring immune repertoire in...

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2490401

The present invention relates generally to methods for stimulating T cells, and more particularly, to methods to eliminate undesired (e.g. autoreactive, alloreactive, pathogenic) subpopulations of T cells from a mixed population of T cells, thereby restoring the normal immune repertoire of said T cells. The present invention also relates to compositions of cells, including stimulated T cells having restored immune repertoire and uses thereof.

La pr~sente invention concerne d'une fa×on g~n~rale des techniques de stimulation des lymphocytes T et, plus particuli­rement des techniques d'~limination de sous populations ind~sirables (par exemple autor~actives, allor~actives, pathog­nes) de lymphocytes T provenant d'une population m~lang~e de lymphocytes T, restaurant ainsi le r~pertoire immunologique normal de ces lymphocytes T. Cette invention concerne aussi des compositions de cellules, notamment des lymphocytes T stimul~s au r~pertoire immunologique restaur~ et des utilisations de celles-ci.

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