Compositions and methods for restoring sensitivity of tumor...

Details Compositions and methods for restoring sensitivity of tumor... Compositions and methods for restoring sensitivity of tumor...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A01N 33/02 (2006.01) A61K 31/135 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2530582

Methods and compositions for restoring sensitivity to the antitumorigenic effects of antiestrogen therapy and/or cytotoxic therapy and inducing cell apoptosis are provided. Contacting tumor cells to GP88 antagonists (e.g., anti- GP88 antibodies, anti-GP88 antisense nucleic acids, GP88 siRNA, and small molecules) induces apoptosis and restores sensitivity to the antitumorigenic effects of antiestrogen therapy and cytotoxic therapy.

L'invention concerne des procédés et des compositions pour rendre à des cellules tumorales leur sensibilité aux effets antitumoraux d'un traitement anti-oestrogène et/ou d'un traitement cytotoxique et induire l'apoptose. La mise en contact des cellules tumorales avec des antagonistes de GP88 (par exemple des anticorps anti-GP88, des acides nucléiques antisens anti-GP88, l'ARN-si GP88 et des petites molécules) induit l'apoptose et redonne aux cellules tumorales leur sensibilité aux effets antitumoraux d'un traitement anti-oestrogène et d'un traitement cytotoxique.

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