Compositions and methods for restoring sensitivity to...

Details Compositions and methods for restoring sensitivity to... Compositions and methods for restoring sensitivity to...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2459622

Methods and compositions for restoring growth inhibition sensitivity to a tumor cell resistant to growth inhibition by HER2 antagonists. The methods involve administering a PCDGF antagonist to the cell in an amount effective to restore growth inhibition sensitivity to HER2 antagonists. The invention also provides treatment regimens, and therapeutic compositions comprising an HER2 antagonist and a PCDGF antagonist.

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