A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61K 38/46 (2006.01) A61K 47/34 (2006.01)
Patent
CA 2702043
The present invention relates generally to conjugates of human ribonucleases and watersoluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer).
L'invention concerne de manière générale des conjugués de ribonucléase humaine et des polymères hydrosolubles, des compositions comprenant les conjugués et des procédés pour les utiliser. La présente invention fournit en particulier des conjugués de ribonucléase humaine et un ou plusieurs polymères hydrosolubles (par exemple pour augmenter la demi-vie sérique et un profil pharmacocinétique, une activité biologique in vivo, une stabilité et/ou pour diminuer une réponse immunitaire d'un hôte à la protéine in vivo) ainsi que des procédés d'utilisation des conjugués dans la thérapie, le traitement et/ou la prévention d'une maladie (par exemple le cancer).
Kink John A.
Raines Ronald T.
Rutkoski Thomas J.
Strong Laura E.
Quintessence Biosciences Inc.
Smart & Biggar
LandOfFree
Compositions and methods for ribonuclease-based therapies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for ribonuclease-based therapies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for ribonuclease-based therapies will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1684278