Compositions and methods for sensitizing and inhibiting...

Details Compositions and methods for sensitizing and inhibiting... Compositions and methods for sensitizing and inhibiting...

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 48/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2320808

Polynucleotides encoding a carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a chemotherapeutic prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing tumor cells to a prodrug chemotherapeutic agent and inhibiting tumor growth with this enzyme are also provided. In addition, screening assay for identification of drugs activated by this enzyme are described.

L'invention concerne des polynucléotides codant une enzyme carboxylestérase et des polypeptides codés par ces polynucléotides et capables de métaboliser un promédicament chimiothérapique et ses métabolites inactifs en médicament actif. Elle concerne également des compositions et des procédés servant à sensibiliser des cellules cancéreuses à un promédicament chimiothérapique et à inhiber la croissance tumorale au moyen de cette enzyme. Elle concerne, de plus, une méthode servant à identifier par criblage des médicaments activés par cette enzyme.

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