C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01) A61P 25/02 (2006.01) C07K 14/705 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2584785
The invention provides short interfering nucleic acids, either single-stranded or double-stranded, that cause RNAi-induced degradation of mRNA from the Nav1.8 sodium channel gene; to pharmaceutical compositions comprising such short interfering nucleic acids; recombinant vectors comprising such short interfering nucleic acids; a method for inhibiting translation of an mRNA; a method for inhibiting expression of a polypeptide; a method for blocking the membrane potential in a cell; a method for blocking the sodium current in a cell; and a method for inhibiting chronic pain.
La présente invention concerne des acides nucléiques courts à interférence, mono brins ou double brins, qui entraînent la dégradation induite par l'ARNi de l'ARNm du gène du canal sodique Nav1.8, des compositions pharmaceutiques comprenant ces acides nucléiques courts à interférence, des vecteurs de recombinaison comprenant ces acides nucléiques courts à interférence, une technique d'inhibition de traduction d'un ARNm, une technique d'inhibition de l'expression d'un polypeptide, une technique permettant de bloquer le potentiel membranaire dans une cellule, une technique permettant de bloquer le courant sodique dans une cellule et une technique d'inhibition de la douleur chronique.
Goregaoker Sameer
Hunter John C.
Priestley Tony
Canji Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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