A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/713 (2006.01) C12N 15/113 (2010.01) A61K 9/14 (2006.01) A61K 9/48 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07H 21/02 (2006.01) C07K 14/775 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2750561
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia).
La présente invention porte sur des compositions qui comportent des acides nucléiques thérapeutiques tels que de l'ARN interférant qui ciblent l'expression du gène de l'apolipoprotéine C-III (APOC3), des particules lipidiques comportant un ou plusieurs (par exemple un cocktail) des acides nucléiques thérapeutiques, des procédés de fabrication des particules lipidiques et des procédés de distribution et/ou d'administration des particules lipidiques (par exemple pour le traitement de maladies ou de troubles lipidiques tels que l'athérosclérose ou une dyslipidémie telle que l'hypertriglycéridémie ou l'hypercholestérolémie).
Lee Amy C. H.
Macdonald Marcia
Maclachlan Ian
Fetherstonhaugh & Co.
Protiva Biotherapeutics Inc.
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