C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2522730
RNA interference using small interfering RNAs which are specific for mRNA produced from the Ang1, Ang2 or Tie2 genes inhibits expression of these genes. Diseases which involve Ang1, Ang2 or Tie2 mediated angiogenesis, such as inflammatory and autoimmune diseases, diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.
La présente invention porte sur l'interférence d'ARN effectuée au moyen d'ARN interférents courts qui sont spécifiques de l'ARNm produit à partir des gènes Ang1, Ang2 ou Tie2 et qui inhibe l'expression de ces gènes. Les maladies qui impliquent l'angiogenèse induite par Ang1, Ang2 ou Tie2, telles que les maladies inflammatoires ou auto-immunes, la rétinopathie diabétique, la dégénérescence maculaire liée à l'âge et plusieurs types de cancer, peuvent être traitées par administration des ARN interférents courts.
Reich Samuel Jotham
Tolentino Michael J.
Borden Ladner Gervais Llp
The Trustees Of The University Of Pennsylvania
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