Compositions and methods for sirna inhibition of angiogenesis

Details Compositions and methods for sirna inhibition of angiogenesis Compositions and methods for sirna inhibition of angiogenesis

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C12N 5/071 (2010.01) C12N 15/113 (2010.01) A61K 9/127 (2006.01) A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2493499

RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt~1 and Flk-l/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.

L'invention concerne l'interférence d'ARN utilisant de petits ARN d'interférence qui sont spécifiques au gène du facteur de croissance vasculaire endothélial (VEGF) et aux gènes récepteurs de VEGF Flt-1 et Flk-l/KDR, qui inhibent l'expression de ces gènes. On peut traiter des maladies liées à l'angiogenèse stimulée par la surexpression de VEGF telles que la rétinopathie diabétique, la dégénérescence musculaire liée au vieillissement et de nombreux types de cancer, et ce grâce à l'administration de petits ARN d'interférence.

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