Compositions and methods for sirna inhibition of hif-1 alpha

Details Compositions and methods for sirna inhibition of hif-1 alpha Compositions and methods for sirna inhibition of hif-1 alpha

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2504926

RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.

Interférence des ARN utilisant des ARN à faible interférence qui ciblent les ARNm des HIF-1 alpha et inhibent l'expression du gène HIF-1 alpha. Comme HIF-1 alpha est aussi un régulateur transcriptionnel de VEGF, l'expression de VEGF est également inhibée. La régulation de la production de VEGF par la régulation vers le bas à méditation par ARNsi des HIF-1 alpha peut s'utiliser pour inhiber l'angiogenèse, notamment lors de maladies telles que la rétinopathie diabétique, la dégénérescence maculaire liée à l'âge et plusieurs cancers.

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