Compositions and methods for sirna inhibition of icam-1

Details Compositions and methods for sirna inhibition of icam-1 Compositions and methods for sirna inhibition of icam-1

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01)

Patent

CA 2513623

RNA interference using small interfering RNAs which are specific for the ICAM- 1 gene inhibits expression of this gene. Diseases which involve ICAM-1- mediated cell adhesion, such as inflammatory and autoimmune diseases, diabetic retinopathy and other complications arising from type I diabetes, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.

L'invention concerne l'utilisation d'ARN, notamment des ARN à faible intervention spécifiques au gène ICAM-1, qui permet d'inhiber l'expression de ce gène. Des maladies qui sont liées à l'adhérence cellulaire à médiation par ICAM-1 telles que les maladies inflammatoires ou auto-immunes, la rétinopathie diabétique et d'autres complications provoquées par le diabète de type I, la dégénérescence maculaire liée à l'âge et plusieurs types de cancer, peuvent être traités par l'administration d'ARN à faible intervention.

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