Compositions and methods for stabilizing biological...

A - Human Necessities – 61 – K

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Details

A61K 39/385 (2006.01) A61K 39/095 (2006.01) A61K 47/22 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2393298

The present invention is directed to compositions and methods for the preparation of biological molecules, in particular MenC-CRM 197. Biological molecules dissolved in dissolution buffers comprising at least one amorphous excipient and an amorphous buffer exhibit reduced aggregation and proteolytic breakdown.

L'invention concerne des compositions et des procédés pour la préparation de molécules biologiques, notamment de MenC-CRM 197. es molécules biologiques dissoutes dans des solutions tampon de dissolution comprenant au moins un excipient amorphe et une solution tampon amorphe présentent une agrégation et une fragmentation protéolytique réduites.

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