Compositions and methods for stimulating antibody class...

Details Compositions and methods for stimulating antibody class... Compositions and methods for stimulating antibody class...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 31/715 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2214726

The invention describes compositions and methods for optimizing IgA class switching in B cells. The compositions comprise a multivalent antigen receptor crosslinker, CD40 ligand or lipopolysaccharide, and the cytokines TGF-.beta., IL-4, and either IL-5 or IL-2. Methods of using the compositions are also described.

L'invention décrit des compositions, ainsi que des techniques correspondantes, permettant d'optimiser la commutation isotypique IgA en cellules B. Ces compositions comportent un agent de réticulation récepteur d'antigène polyvalent, un ligand CD40 ou un lipopolysaccharide ainsi que les cytokines TGF-.beta., IL-4, et soit IL-5, soit IL-2. Sont également décrites des techniques d'application de ces compositions.

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