Compositions and methods for systemic inhibition of...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 38/17 (2006.01) A61P 19/04 (2006.01)

Patent

CA 2474645

Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.

L'invention concerne des méthodes et des compositions d'inhibition de la dégradation du cartilage articulaire. Les compositions comprennent, de préférence, de multiples agents chondroprotecteurs, comprenant au moins un agent favorisant l'activité anabolique du cartilage et au moins un agent d'inhibition du catabolisme du cartilage. Les compositions peuvent également comprendre un ou plusieurs agents d'inhibition de la douleur ou de l'inflammation. Les compositions peuvent être administrées de façon systémique, par exemple pour traiter les patients à risque pouvant présenter une dégradation du cartilage au niveau de multiples articulations, et peuvent être formulées de manière appropriée dans un excipient ou véhicule d'administration ciblant les articulations. En variante, les compositions peuvent être injectées ou administrées par perfusion directement dans l'articulation.

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