A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C12N 5/00 (2006.01)
Patent
CA 2512717
The present invention relates generally to compositions adapted to provide delivery of therapeutic, diagnostic, prophylactic, or imaging molecules across polarized cells, and methods of their use. By associating two or more targeting elements in or with the composition, one of which binds to a first cell surface component, and another that binds to a second component of the cell that is not initially available to the composition in an amount sufficient to promote effective delivery of all or a portion of the composition into and/or across polarized cells, the compositions of the present invention can provide enhanced bioavailability of medically-relevant moieties.
La présente invention concerne généralement des compositions conçues pour transporter des molécules à des fins thérapeutiques, diagnostiques, prophylactiques ou d'imagerie, à travers des cellules polarisées; ainsi que des méthodes d'utilisation de ces compositions. En associant deux ou plusieurs éléments de ciblage dans ou à la composition, dont l'un se lie à un premier élément de surface cellulaire, et l'autre à un second élément de la surface qui, au départ, n'était pas disponible pour la composition dans des quantités suffisantes pour promouvoir le transport effectif de tout ou partie de la composition dans et/ou à travers des cellules polarisées, les compositions de l'invention peuvent assurer une biodisponibilité améliorée de fragments intéressants d'un point de vue médical.
Chapin Steven J.
Domingo Derrick
Sheridan Philip Lee
Arizeke Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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