Compositions and methods for targeted delivery of immune...

A - Human Necessities – 61 – K

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A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2598144

The present invention provides immunomodulatory compositions include an immune response modifier moiety coupled to a targeting moiety. In another aspect, the invention provides methods of providing targeted delivery of an IRM, generating a localized immune response, and treating a condition in a subject. Generally, the methods include administering to the subject an immunomodulatory composition that includes an immune response modifier moiety coupled to a targeting moiety that recognizes a delivery target.

L'invention concerne des compositions immunomodulatrices qui comprennent une fraction d'agent modifiant la réaction immunitaire, couplée à une fraction de ciblage. Dans un autre aspect, l'invention concerne des procédés d'apport ciblé d'un agent modifiant la réaction immunitaire, qui comportent les étapes consistant à: produire une réaction immunitaire localisée, et traiter un état pathologique chez un sujet. De manière générale, les procédés comportent les étapes consistant à: administrer au sujet une composition immunomodulatrice comprenant une fraction d'agent modifiant la réaction immunitaire, couplée à une fraction de ciblage destinée à reconnaître la cible visée.

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