Compositions and methods for the detection and treatment of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 31/00 (2006.01) A61K 31/137 (2006.01) A61K 31/275 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61K 31/4422 (2006.01) A61K 31/55 (2006.01) A61K 31/554 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/85 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2169210

The present invention provides compositions and methods for increasing secretory protein production. In another aspect, the present invention provides compositions for use in methods of treating and diagnosing protein trafficking disorders. These methods generally involve the alteration of calnexin activity to increase protein secretion or retention.

Cette invention concerne des compositions et des procédés d'accroissement des sécrétions protéiniques. En outre, cette invention concerne des compositions à utiliser pour les procédés de traitement et de diagnostic des troubles des échanges entre protéines. Ces procédés interviennent généralement au niveau de l'activité calnexinique de façon à accroître la sécrétion ou la rétention protéinique.

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