C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) C12N 5/20 (2006.01) C12N 15/06 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2516191
Compositions and methods involving agents that specifically bind to methylthioadenosine phosphorylase (MTAP) protein are disclosed. Illustrative compositions comprise binding agents that bind to human MTAP protein in biological samples, including embedded samples. The binding agents are useful, for example, in the detection, prognosis, and/or treatment of MTAP deficient cancers. Also disclosed are kits containing the reagents necessary for the detection of human MTAP protein in an embedded sample.
L'invention concerne des compositions et des méthodes faisant appel à des agents se liant spécifiquement à une protéine de méthylthioadénosine phosphorylase (MTAP). Les compositions de cette invention contiennent des agents liants se liant à une protéine humaine MTAP dans des échantillons biologiques, y compris des échantillons inclus. Les agents liants sont utiles, par exemple, dans la détection, le pronostic et/ou le traitement de cancer à déficience de MTAP. Font également l'objet de cette invention des kits contenant les réactifs nécessaires à la détection d'une protéine humaine MTAP dans un échantillon inclus.
Cephalon Inc.
Mbm Intellectual Property Law Llp
Salmedix Inc
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