Compositions and methods for the detection, diagnosis and...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 48/00 (2006.01) C07K 14/735 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2463659

Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.

L'invention concerne des procédés et des compositions pour la détection, le diagnostic et la thérapie de malignités hématologiques, et en particulier les leucémies B, les lymphomes et les myélomes multiples. On décrit des compositions, des procédés et des kits permettant d'induire des réponses immunitaires et lymphocytaires aux polypeptides antigéniques liés à des malignités spécifiques, y compris leurs fragments, chez un animal. L'invention concerne également des compositions et des procédés pour l'identification de cellules et d'échantillons biologiques renfermant une ou plusieurs compositions liées à des malignités hématologiques, et des procédés relatifs à la détection et au diagnostic de ce type de maladie et des types de cellules affectées. L'invention concerne enfin des kits diagnostiques et thérapeutiques, ainsi que des procédés pour le diagnostic, la thérapie et/ou la prévention d'un éventail de leucémies et de lymphomes.

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