Compositions and methods for the diagnosis and therapy of...

A - Human Necessities – 61 – K

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A61K 31/7088 (2006.01) C07H 21/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2621441

The invention provides methods and compositions for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and methods and compositions for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy. The invention also encompasses methods for determining the efficacy of a cancer therapy in a subject and methods for inducing apoptosis of a cell.

L'invention concerne des méthodes et des compositions pour le traitement de cancers associés à une surexpression d'un gène BCL2 et/ou d'un produit génique chez un sujet, ainsi que des méthodes et des compositions pour l'amélioration de la thérapie anticancéreuse, telle que la chimiothérapie et la radiothérapie. L'invention concerne également des méthodes pour déterminer l'efficacité d'une cancérothérapie chez un sujet ainsi que des méthodes pour induire l'apoptose d'une cellule.

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