C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) C07K 14/475 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2416538
Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
La présente invention concerne des compositions et des méthodes permettant de stimuler ou d'inhiber l'angiogenèse et/ou la vascularisation cardiaque chez les mammifères, notamment les humains. Ces compositions pharmaceutiques renferment des polypeptides ou leurs antagonistes ayant été identifiés pour un ou plusieurs de ces usages. Parmi les troubles pouvant être diagnostiqués, prévenus, ou traités avec ces compositions, on note les traumas tels que les blessures, divers cancers, et les troubles vasculaires, notamment l'athérosclérose et l'hypertrophie cardiaque. Par ailleurs, l'invention concerne de nouveaux polypeptides et des molécules d'acides nucléiques codant ces polypeptides. Cette invention concerne également des vecteurs et des cellules hôtes contenant ces séquences d'acides nucléiques, des molécules de polypeptides chimères contenant les polypeptides de l'invention fusionnés aux séquences de polypeptides hétérologues, des anticorps qui se lient à ces polypeptides, ainsi que des méthodes de production desdits polypeptides.
Baker Kevin P.
Ferrara Napoleone
Gerber Hanspeter
Gerritsen Mary E.
Goddard Audrey
Dennison Associates
Genentech Inc.
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