Compositions and methods for the early diagnosis of ovarian...

Details Compositions and methods for the early diagnosis of ovarian... Compositions and methods for the early diagnosis of ovarian...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/17 (2006.01) A61K 38/43 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/435 (2006.01) C12N 9/64 (2006.01) C12P 19/34 (2006.01) C12Q 1/37 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2402017

The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue (cDNA), can indicate the presence of specific proteases in a tissue sample. The detected proteases are themselves specifically overexpressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.

L'invention se rapporte à des ensembles d'amorces d'acides nucléiques, utilisés en association à une amplification quantitative (PCR) d'ADNc tissulaire, qui peuvent indiquer la présence de protéases spécifiques dans un prélèvement tissulaire. Les protéases détectées sont elles-mêmes surexprimées spécifiquement dans certains cancers, et leur présence peut permettre une détection précoce de tumeurs ovariennes et autres, ainsi que l'élaboration de thérapies interactives permettant de traiter le cancer.

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