Compositions and methods for the endocytic presentation of...

C - Chemistry – Metallurgy – 07 – K

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C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61P 37/06 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2416656

Immunomodulating agents comprising at least one Fc receptor ligand and at least one immunosuppressive factor are provided as are methods for their manufacture and use. The immunomodulating agents may be in the form of polypeptides or chimeric antibodies and preferably incorporate an immunosuppressive factor comprising a T cell receptor agonist or antagonist. The compounds and compositions of the invention may be used to selectively suppress the immune system to treat symptoms associated with immune disorders such as allergies, transplanted tissue rejection and autoimmune disorders including autoimmune diabetes, rheumatoid arthritis and multiple sclerosis.

La présente invention concerne des agents immunomodulateurs qui comprennent au moins un ligand du récepteur Fc et au moins un facteur immunosuppresseur, de même que des techniques de préparation et d'utilisation de ces agents. Ces agents immunomodulateurs peuvent prendre la forme de polypeptides ou d'anticorps chimériques et ils comprennent, de préférence, un facteur immunosuppresseur comprenant un agoniste ou un antagoniste du récepteur de lymphocyte T. Les composés et les compositions de cette invention peuvent être utilisés pour supprimer de façon sélective le système immunitaire afin de traiter des symptômes associés à des troubles du système immunitaire telles que des allergies, le rejet de tissus greffés et des maladies auto-immunes comprenant le diabète auto-immun, l'arthrite rhumatoïde et la sclérose en plaques.

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