Compositions and methods for the generation of protective...

Details Compositions and methods for the generation of protective... Compositions and methods for the generation of protective...

A - Human Necessities

61

K

A61K 39/015 (2006.01) A61P 33/06 (2006.01)

Patent

CA 2545779

The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semiconserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.

La présente invention concerne des formulations de vaccin contenant des épitopes fortement antigéniques identifiés au sein de la boucle I semi-conservée du domaine III, qui sont capables d'induire des anticorps inhibiteurs de la croissance des parasites. Les peptides linéaires ou cyclisés peuvent être administrés à l'aide d'adjuvants connus ou peuvent être encapsulés par des liposomes ou virosomes (IRIVs) ou attachés sur la surface desdits liposomes ou virosomes qui servent de systèmes d'administration d'antigènes à compatibilité humaine. Les versions tant cyclisées que linéaires des antigènes peptidiques sont étonnamment efficaces pour induire des réponses immunitaires qui se trouvent en réaction croisée avec AMA-1 exprimé par les parasites.

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