C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 45/00 (2006.01)
Patent
CA 2267138
A method of predicting the clinical outcome of patients suffering from congestive heart failure by identifying patients with a mutant allele of the AMPD1 gene is provided. Methods for increasing survival time in patients suffering from congestive heart failure by administering compositions which inhibit AMPD1 activity are also provided.
Méthode permettant de prévoir l'issue clinique dans le cas des patients souffrant d'une insuffisance cardiaque globale; la méthode consiste à identifier les patients à mutant allèle du gène de la désaminase d'adénosine-monophosphate 1. L'invention propose également des méthodes permettant de prolonger la durée de vie des patients souffrant d'une insuffisance cardiaque globale, qui consistent à leur administrer des compositions inhibant l'activité de la désaminase d'adénosine-monophosphate 1.
Holmes Edward
Loh Evan
Swain Judith
Borden Ladner Gervais Llp
The Trustees Of The University Of Pennsylvania
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