C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2743057
The present invention provides methods compositions and methods for treating a hyperproliferative disease comprising disrupting Cripto/GRP78 complex formation in a hyperproliferative cell. In certain embodiments, an antibody and/or siRNA may be used to inhibit Cripto/GRP78 binding, optionally coupled with other cancer therapies. Also provided are methods for identifying therapeutic compounds which can selectively inhibit Cripto/GRP78 binding.
La présente invention porte sur des compositions et des méthodes permettant de traiter une maladie hyperproliférative, comprenant l'interruption de la formation du complexe Cripto/GRP78 dans une cellule hyperproliférative. Dans certains modes de réalisation, un anticorps et/ou un ARNsi peuvent être utilisés pour inhiber la liaison de Cripto/GRP78, facultativement couplés à d'autres thérapies anticancéreuses. L'invention porte également sur des procédés permettant d'identifier des composés thérapeutiques qui peuvent sélectivement inhiber la liaison de Cripto/GRP78.
Gray Peter C.
Kelber Jonathan A.
Shani Gidi
Vale Wylie
Borden Ladner Gervais Llp
Research Development Foundation
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