Compositions and methods for the modulation of sphingolipid...

Details Compositions and methods for the modulation of sphingolipid... Compositions and methods for the modulation of sphingolipid...

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) C12N 9/88 (2006.01) C12P 21/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2473680

Compositions, methods and kits for diagnosing and treating cancer and muscular disorders are provided. Therapeutic compositions may comprise agents that modulate sphingolipid metabolism and/or signaling pathways. Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations in endogenous genes involved in sphingolipid metabolism. Such methods and kits may be used to detect the presence of a cancer or to evaluate the prognosis of a known disease. SPL polypeptides, polynucleotides and antibodies are also provided.

La présente invention concerne des compositions, des procédés et des trousses destinés au traitement du cancer et d'affections musculaires. Les compositions thérapeutiques de l'invention peuvent comprendre des agents qui modulent le métabolisme et/ou les voies de signalisation des sphingolipides. Les compositions précitées peuvent être administrées à un mammifère atteint d'un cancer.Les procédés et trousses diagnostiques peuvent faire appel à un agent apte à détecter des modifications dans des gènes endogènes impliqués dans le métabolisme des sphingolipides. On peut utiliser les procédés et trousses précités pour détecter la présence d'un cancer ou évaluer le pronostic d'une maladie connue. L'invention se rapporte également à des polypeptides, des polynucléotides et des anticorps sphingolipidiques.

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