C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/27 (2006.01) A61K 47/48 (2006.01) A61P 5/06 (2006.01) C07K 14/61 (2006.01) C07K 17/08 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2524936
The present invention relates to mutants of human growth hormone, which contain newly introduced N-linked or O-linked glycosylation site(s), such that these recombinantly produced polypeptides have glycosylation patterns distinctly different from that of the naturally occurring human growth hormone. The polynucleotide coding sequences for the mutants, expression cassettes comprising the coding sequences, cells expressing the mutants, and methods for producing the mutants are also disclosed. Further disclosed are pharmaceutical compositions comprising the mutants and method for using the mutants.
L'invention concerne des mutants de l'hormone de croissance humaine, contenant des sites de glycosylation sur la liaison N ou la liaison O, de sorte que les polypeptides produits de manière recombinée présentent des circuits de glycosylation différents de manière distincte de ceux apparaissant naturellement dans l'hormone de croissance humaine. L'invention concerne également lesdites séquences de codage de polynucléotides pour les mutants, les cassettes d'expression comprenant les séquences de codage, les cellules exprimant les mutants, et des procédés pour produire les mutants. L'invention concerne, en outre, des compositions pharmaceutiques comprenant les mutants et un procédé pour utiliser lesdits mutants.
Clausen Henrik
Defrees Shawn
Gowling Lafleur Henderson Llp
Neose Technologies Inc.
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