A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 31/337 (2006.01) A61K 31/355 (2006.01) A61K 38/28 (2006.01) A61K 47/34 (2006.01) A61K 47/44 (2006.01)
Patent
CA 2719803
The disclosure relates to compositions and methods of forming nanoemulsions, e.g., containing an active component, in combination with lipophilic components such as oils, hydrophilic components such as water, and one or more surfactants capable of causing a temperature-dependent phase inversion, such as a nonionic polyethoxylated surfactant. Nanoemulsions containing the active component can be produced having average oil droplet sizes of less than 100 nm, 50 nm, or 25 nm without the need for high energy emulsion forming methods (such as microfluidization) by combining the surfactant and the oil in specified weight ratios (e.g., at least 3:1) prior to forming the nanoemulsion.
L'invention concerne des compositions et procédés de formation de nanoémulsions, contenant par exemple un composant actif, combiné à des composés lipophiles tels que des huiles, des composés hydrophiles tels que l'eau et au moins un agent tensioactif capable de provoquer une inversion de phase en fonction de la température, tel qu'un agent tensioactif polyéthoxylé non ionique. Les nanoémulsions contenant le composant actif peuvent être produites avec des tailles de gouttelettes d'huile moyennes inférieures à 100 nm, 50 nm ou 25 nm sans recourir à des procédés de formation d'émulsion hautement énergétiques (tels que la microfluidisation) en combinant l'agent tensioactif et l'huile dans des rapports pondéraux spécifiés (par exemple au moins 3:1) avant de former la nanoémulsion.
Kakumanu Srikanth
Konecni Shawn
Kuo Fonghsu
Lawton Carl W.
Nicolosi Robert J.
Gowling Lafleur Henderson Llp
University Of Massachusetts
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