C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) C07K 14/29 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2268013
Methods and compositions for the prevention, treatment and diagnosis of human granulocytic ehrlichiosis. aoHGE polypeptides, serotypic variants thereof, fragments thereof and derivatives thereof. Fusion proteins and multimeric proteins comprising same. Vaccines comprising aoHGE polypeptides alone or in addition to other protective aoHGE polypeptides. DNA sequences, recombinant DNA molecules and transformed host cells useful in the compositions and methods. Antibodies directed against the aoHGE polypeptides, and diagnostic kits comprising the polypeptides or antibodies.
L'invention concerne des procédés et compositions destinés à la prévention, au traitement et au diagnostic de l'ehrlichiose granulocytaire humaine, de même que des polypeptides de l'agent de cette ehrlichiose (aoHGE), des variants à type sérologique, fragments et dérivés des polypeptides, ainsi que des protéines de fusion et des protéines multimères comprenant ces polypeptides. L'invention concerne encore des vaccins comprenant les polypeptides de aoHGE seuls ou ajoutés à d'autres polypeptides de protection contre aoHGE, et elle concerne également des séquences d'ADN, des molécules d'ADN recombiné et des cellules hôtes transformées, utiles dans les compositions et procédés de l'invention, ainsi que des anticorps dirigés contre les polypeptides de aoHGE, et des trousses de diagnostic comprenant ces polypeptides ou anticorps.
Barthold Stephen W.
Fikrig Erol
Ijdo Jacob
Sun Wei
Smart & Biggar
Yale University
LandOfFree
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