Compositions and methods for the prevention and treatment of...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2680227

The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.

L'invention concerne des procédés comprenant la réduction ou le développement sélectif de lymphocytes T selon la spécificité antigénique des lymphocytes T. En conséquence, la présente invention peut être utilisée pour réduire ou éliminer les lymphocytes T pathogènes qui reconnaissent les auto-antigènes, tels que les lymphocytes T spécifiques des cellules bêta. La présente invention peut être utilisée en tant que telle pour prévenir, traiter ou améliorer les pathologies auto-immunes telles que le diabète de type I. En outre, la présente invention peut être utilisée pour développer les lymphocytes T souhaitables, tels que les lymphocytes T anti-pathogènes, afin de prévenir, traiter ou améliorer les pathologies auto-immunes.

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