Compositions and methods for the prevention of oxidative...

Details Compositions and methods for the prevention of oxidative... Compositions and methods for the prevention of oxidative...

A - Human Necessities

61

K

A61K 38/29 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2734275

The invention relates to pharmaceutical formulations comprising a protein and free methionine in combination with one or more compounds capable of preventing the oxidation of aromatic amino acid residues within a protein. More specifi-cally, the invention relates to stabilized, pharmaceutically effective preparations of oxidation-sensitive therapeutic agents. The in-vention further relates to a method of inhibiting the oxidation of such therapeutic agents.

Linvention concerne des formules pharmaceutiques contenant une protéine et de la méthionine libre en combinaison avec un ou plusieurs composés capables dempêcher loxydation des résidus dacides aminés aromatiques se trouvant dans une protéine. Plus précisément, linvention concerne des préparations stabilisées efficaces sur le plan pharmaceutique contenant des agents thérapeutiques sensibles à loxydation. Linvention concerne en outre un procédé permettant dinhiber loxydation de ces agents thérapeutiques.

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