Compositions and methods for the prophylaxis and treatment...

A - Human Necessities – 61 – K

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Details

A61K 33/34 (2006.01) A61K 31/56 (2006.01) A61K 33/24 (2006.01) A61K 33/32 (2006.01)

Patent

CA 2484514

Disclosed is a topical method for providing adequate analgesic, anti- inflammatory, antimicrobial and tissue-regenerating activities for the hitherto most effective prophylaxis and treatment of aphtous ulcers and herpes simplex lesions and for the effective treatment of burns and other oral mucosal ulcers comprising topically administering to the affected tissue an effective amount of a composition comprised of one or more safe and efficacious polyvalent metal compounds such as magnesium sulfate, preferably with one or more safe and efficacious anti-inflammatory compounds, such as a novel ultra-low-strength hydrocortisone (acetate), that potentiate the activities of polyvalent metal compounds. Both the ionic and neutral moieties of the polyvalent metals are pharmacologically active; water-soluble and water- insoluble polyvalent metal compounds are both therapeutically effective.

La présente invention concerne un procédé topique permettant d'exercer un effet analgésique, anti-inflammatoire et anti-microbien et une action de régénération des tissus pour prévenir et traiter avec efficacité les ulcérations aphteuses et les lésions dues à l'herpès ainsi que pour traiter avec efficacité les brûlures et les autres ulcères de la muqueuse orale. Ce procédé consiste à administrer par voie topique au tissu affecté une quantité efficace d'une composition comprenant un ou plusieurs composés métalliques polyvalents, comme du sulfate de magnésium, de préférence, avec un ou plusieurs composés anti-inflammatoires sûrs et efficaces comme de l'acétate d'hydrocortisone à ultra faible dosage, qui renforcent l'action des composés métalliques polyvalents. Les fractions ioniques et neutres des métaux polyvalents sont pharmacologiquement actives ; Les composés métalliques polyvalents solubles à l'eau et insolubles à l'eau présentent une efficacité thérapeutique.

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