Compositions and methods for the pulmonary delivery of...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A61K 47/34 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2333087

The present invention relates to compositions and methods for the pulmonary delivery of nucleic acids, particularly oligonucleotides. In one preferred embodiment, the compositions and methods of the invention are utilized to effect the pulmonary delivery of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic or prophylactic purposes.

L'invention concerne des compositions et des méthodes d'administration aux poumons d'acides nucléiques, notamment des oligonucléotides. Dans un mode de réalisation préféré, les compositions et les méthodes selon l'invention servent à administrer aux poumons d'un animal un oligonucléotide antisens, de manière à moduler l'expression d'un gène de l'animal à des fins thérapeutiques, prophylactiques ou de recherche scientifique.

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