Compositions and methods for the reduction of post-operative...

A - Human Necessities – 61 – K

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A61K 9/22 (2006.01) A61F 13/00 (2006.01) A61M 31/00 (2006.01)

Patent

CA 2616384

At least three component, body-implantable, absorbable, biocompatible, putty, and non-putty pain-relieving compositions for use in surgery comprising in intimate admixture: an analgesic having local pain-relieving activity for internal relief of pain, a finely powdered bulking material, preferably less than 50 microns, e.g. the metal salts of fatty acid, hydroxyapatite, DBM, polyglycolide, polylactide, polycaprolactones, absorbable glasses, gelatin, collagens, mono, and polysaccharides starches. An organic liquid capable of solubilizing, dispensing or suspending the analgesic, such as esters of monohydric alcohols with aliphatic monocarboxylic acids; C2-C18 monohydric alcohols with polycarboxylic acids; C8-C30 monohydric alcohols; tocopherol and esters thereof with mono or polycarboxylic acids; free carboxylic acids such as oleic, capric, and lauric; dialkyl ethers and ketones; polyhydroxy compounds and esters and ethers thereof; random or block copolymers of ethylene oxide and propylene oxide.

L'invention concerne des compositions analgésiques à trois composants au moins implantables dans le corps, absorbables, biocompatibles, pâteuses, et non pâteuses utilisées en chirurgie, qui comprennent en un mélange intime: un analgésique ayant une activité analgésique locale qui soulage la douleur interne, une matière gonflante en poudre fine, de préférence inférieure à 50 microns, par exemple les sels métalliques d'acide gras, d'hydroxyapatite, de DMB, de polyglycolide, de polylactide, de polycaprolactones, de verres résorbables, de gélatine, de collagènes, d'amidons monosaccharides et polysaccharides. Elle concerne en outre un liquide organique susceptible de solubiliser, de distribuer ou de suspendre l'analgésique, par exemple des esters d'alcools monohydriques, avec des acides monocarboxyliques aliphatiques, des alcools monohydriques C2-C18 avec des acides polycarboxyliques; des alcools monohydriques C8-C30, leurs tocophérols et esters avec des acides monocarboxyliques ou polycarboxyliques; des acides carboxyliques libres, par exemple acides oléique, caprique, et laurique; des dialkyléthers et des cétones; des composés polyhydroxy et des esters ainsi que leurs éthers; des copolymères aléatoires ou en blocs d'oxyde d'éthylène et d'oxyde de propylène.

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