A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/09 (2006.01) A61K 9/00 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/44 (2006.01)
Patent
CA 2103163
Pharmaceutical compositions for the sublingual or buccal administration of therapeutic agents (particularly polypeptides) which are normally degraded upon oral administration comprise such a therapeutic agent, a solvent, optionally a cosolvent and/ or hydrogel, and an oral mucosal membrane transport enhancing agent which is selected from the group consisting of essential and volatile oils and inorganic acids.
L'invention porte sur des compositions pharmaceutiques pour l'administration sublinguale ou buccale d'agents thérapeutiques (plus particulièrement des polypeptides) qui habituellement se dégradent au moment de l'administration par voie orale. Les compositions comprennent un tel agent thérapeutique, un solvant, un cosolvant et/ou un hydrogel au choix, et un agent favorisant le transport à travers la membrane des muqueuses buccales, lequel est sélectionné parmi un groupe composé d'huiles essentielles et d'acides inorganiques.
Fu Lu Mou-Ying
Reiland Thomas L.
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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