C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 5/0783 (2010.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2446788
Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
L'invention concerne des compositions et des procédés pour la thérapie et le diagnostic du cancer, notamment du cancer de la prostate. Les compositions selon l'invention comprennent un ou plusieurs polypeptides spécifiques de la prostate, des parties immunogéniques de ces polypeptides, des polynucléotides codant pour de tels polypeptides, une cellule présentatrice d'antigène qui exprime de tels polypeptides, ainsi que des cellules T spécifiques de cellules exprimant de tels polypeptides. Les compositions selon l'invention servent, par exemple, au diagnostic, à la prévention ou au traitement de maladies, notamment du cancer de la prostate.
Carter Darrick
Day Craig H.
Deng Ta
Dillon Davin C.
Fanger Gary R.
Borden Ladner Gervais Llp
Corixa Corporation
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