C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C07K 14/71 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2419533
Compositions and methods for the therapy and diagnosis of cancer, particularly Her-2/neu-associated cancers, are disclosed. Illustrative compositions comprise one or more Her-2/neu polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of Her-2/neu-associated malignancies.
L'invention concerne des compositions et des méthodes de traitement et de diagnostic de cancers, en particulier les cancers associés à Her-2/neu. Des compositions exemplaires comprennent un ou plusieurs polypeptides Her-2/neu, des parties immunogènes desdits polypeptides, des polynucléotides codant ces polypeptides, une cellule présentatrice de l'antigène exprimant ces polypeptides, et des lymphocytes T spécifiques de cellules exprimant ces polypeptides. Les compositions de l'invention sont utiles, par exemple, pour le diagnostic, la prévention et/ou le traitement de cancers associés à Her-2/neu.
Cheever Martin A.
Foy Teresa M.
Hand-Zimmermann Susan
Kalos Michael D.
Lodes Michael J.
Corixa Corporation
Gowling Lafleur Henderson Llp
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