C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2406213
Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
L'invention porte sur des compositions et procédés de traitement et de diagnostic de cancers tels que le cancer du sein. Lesdites compositions comprennent une ou plusieurs protéines de tumeurs du sein, de leurs parties immunogènes et les polynucléotides codant pour lesdites parties. En variante, la composition thérapeutique peut comporter une cellule portant un antigène exprimant une protéine tumorale ou une cellule T spécifique de cellules exprimant ladite protéine. Ces compositions peuvent par exemple servir à la prévention et au traitement de maladies telles que le cancer du sein. L'invention porte également sur des méthodes de diagnostic basées sur la détection dans un prélèvement, d'une protéine de tumeurs du sein ou de l'ARNm codant pour elle.
Dillon Davin C.
Harlocker Susan L.
Hepler William T.
Jiang Yuqiu
Mitcham Jennifer L.
Corixa Corporation
Gowling Lafleur Henderson Llp
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