Compositions and methods for the therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2412223

Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

L'invention concerne des compositions et des procédés servant à traiter et à diagnostiquer le cancer, tel que le cancer du colon. Ces compositions peuvent contenir une ou plusieurs protéines de tumeur du colon, des parties immunogènes de ces protéines ou des polynucléotides codant ces parties. Dans un autre mode de réalisation, une composition thérapeutique peut contenir une cellule de présentation d'antigène exprimant une protéine de tumeur du colon ou un lymphocyte T spécifique pour des cellules exprimant cette protéine. On peut utiliser, par exemple, ces compostions pour la prévention et le traitement de maladies, telles que le cancer du colon. L'invention concerne également des méthodes diagnostiques basées sur la détection d'une protéine de tumeur du colon ou de l'ARNm codant cette protéine, dans un spécimen.

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