Compositions and methods for the therapy and diagnosis of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2414596

Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

L'invention concerne des compositions et des méthodes de diagnostic et de traitement d'un cancer, tel que le cancer des poumons. Ces compositions peuvent comprendre une ou plusieurs protéines de la tumeur du poumon, des parties immunogènes de ces protéines, ou des polynucléotides codant ces parties. Dans un autre aspect, une composition thérapeutique peut comprendre une cellule présentant un antigène qui exprime une protéine de la tumeur du poumon, ou une cellule T qui est spécifique pour des cellules exprimant une telle protéine. Ces compositions peuvent être utilisées, par exemple, pour la prévention et le traitement de maladies telles que le cancer des poumons. L'invention concerne en outre des méthodes diagnostiques qui consistent à détecter, dans un prélèvement, une protéine de la tumeur du poumon ou un ARNm codant cette protéine.

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